关键信息

    该文作者研究了高肌钙蛋白水平与血小板活化标志物与社区获得性肺炎患者心肌梗死的发生的关系。在具有高肌钙蛋白T的144例病患中，只有31例具有心肌梗死的特征，且血浆可溶性P-选择素，可溶性CD40配体，和血浆血栓素B2水平显著升高。总的来说，接受100毫克/天阿司匹林与否与心肌梗死的发病率并无关系(12% vs 10%; P =0 .649。在接受阿司匹林治疗的患者中，心梗患者与非心梗患者相比具有更高的血清血栓素B2水平。

    每天服用阿司匹林治疗（100mg/d）似乎不足以抑制住院治疗的获得性肺炎患者血清血栓素B2的产生。

    TAKE-HOME MESSAGE

    The authors of this study examined the association between raised troponin levels and markers of platelet activation and the occurrence of myocardial infarction in patients with community-acquired pneumonia. Of 144 patients with high cardiac troponin T, only 31 had features of MI and significantly higher levels of plasma soluble P-selectin, soluble CD40 ligand, and serum thromboxane B2. Overall, the incidence of MI did not differ significantly between those patients who received aspirin 100 mg/day and those who did not (12% vs 10%; P = .649). Among all patients who received daily aspirin treatment, those with MIs had higher levels of serum thromboxane B2 compared with those without MIs (P = .005).

    Daily aspirin therapy (100 mg/day) appears inadequate to prevent production of serum thromboxane B2 in patients hospitalized for community-acquired pneumonia.