Biocompatibility and clinical application of hernia patch material

Zhang Pan

Abstract

OBJECTIVE : To evaluate the performance and application prospects of hernia patch materials, and to look for a reasonable hernia repair material.

METHODS: Wanfang database (http://www.wanfangdata.com.cn/) from January 1999 to December 2009 was retrieved on computer for articles related with the biomaterials used in hernia repair, using keywords of "tissue engineering in Chinese .The repeated study ,general review or Meta analysis were excluded, totally 25 articles were involved in evaluation.

RESULTS: The traditional non-degradable biomaterials are only be used as hernia filling materials, with the development of medicine and tissue engineered techniques, various synthetic biomaterials have emerged. Currently used hernia repair materials include non-absorbing materials such as polypropylene, and absorbable material, such as polyglycolic acid mesh and composite materials. Through the stimulation between the organism and the patch, these materials produce different reactions, alternative repair materials may occur in future, that is to repair various wounds according to different materials. It is one of hot spots in research of biomedical engineering that to use autologous cells and dermal materials to complete hernia repair.　　CONCLUSION: Although polypropylene and polyglycolic acid mesh are commonly applied in clinical practice for hernia repair, hernia repair materials need further development because of their inevitable shortcomings.

【摘要】

目的 评价疝补片材料的性能及应用前景,寻找合理的腹外疝修补材料。
方法 采用电子检索的方式,在万方数据库(http：//wwanfangdata. com. cn/中检索199901/200912有关生物材料应用于腹外疝修补的研究文章,关键词为“组织工程,腹外疝,生物材料”。排除重复研究、普通综述或Meta分析类文章,筛选纳入25篇文献进行评价。
结果 传统的非降解生物材料仅可作为腹外疝的填充材料,随着医学和组织工程技术的发展,各种合成生物材料相继出现目前国内使用的腹外疝修补材料分为不可吸收材料和可吸收材料,不可吸收材料如聚丙烯材料,可吸收材如聚羟基乙酸网以及复合型疝修补材等。这些材料通过机体与补片的刺激,而产生不同的反应,今后可能会出现选择修补材料,即根据不同的材料来修补不同的的伤口。而利用自体细胞和真皮材料完成腹外疝的修补是当前生物医学工程研究的热点之一。
结论 虽然聚丙烯、聚羟基乙酸网材料是目前临床上大量使用的腹外疝修补材料,但由于其存在各自不可避兔的缺点,腹外疝修补材料仍需进一步开
关键词 腹外疝；材料；修补；生物相容性；组织工程