过氧化物酶体增殖物激活受体α(pparα)扮演关键角色A在调节代谢反应空腹和抗炎通路抑制剂)是在免疫细胞。它代表的治疗目标为A治疗一些疾病，主要hyperlipidemia。在表达的变化pparα棚灯在回应空腹年轻健康的女性志愿者，多次与美联储或是fasted为24小时。每2小时或是一个编译时分析mRNA和蛋白表达的两个配置文件pparα大学学院和它的互动合作伙伴，脑和心脏起搏器“芳烃受体核转位蛋白肌肉样1(BMAL1)。我们发现，女性的表达变化diurnal大学当交换文件pparαBMAL1和从美联储的fasted状态，而男性不。interestingly，pparαBMAL1和配置文件的人和妇女在美联储状态是不同的配置文件，而在fasted状态是几乎相同的。一次调查diametrically学院对面的响应和在美联储女性pparα表达状态可能有在医学实践型人力pparαactivators AS样fibrates是用于治疗慢性淋巴细胞白血病的并发症，糖尿病和肾脏microvascular，diseases.途径，N.，schutkowski，A.，boenn，M.，bialek，J.，schlitt A. F. Noack，F.，男性和女性的不同的表达过氧化物酶体增殖物激活受体α将不同。

　　原文

　　Men and women differ in their diurnal expression of monocyte peroxisome proliferator-activated receptor-α in the fed but not in the fasted state

　　Abstract

　　Peroxisome proliferator-activated receptor-α (PPARα) plays a pivotal role in regulating metabolic response to fasting and is an inhibitor of inflammatory pathways in immune cells. It represents a therapeutic target for treatment of several diseases, mainly hyperlipidemia. To shed light on PPARα expression changes in response to fasting, young healthy male and female volunteers were fed or fasted for 24 hours. Monocytes were analyzed every 2 hours to compile both profiles of mRNA and protein expression of PPARα and its interactive partner, the circadian pacemaker brain and muscle aryl hydrocarbon receptor nuclear translocator like-1 (BMAL1). We found that women change their diurnal expression profiles of PPARα and BMAL1 when switching from the fed to the fasted state, whereas men do not. Interestingly, the PPARα and BMAL1 profiles of men and women in the fed state are different, whereas the profiles in the fasted state are virtually identical. The finding of diametrically opposite responses of male and female PPARα expression in the fed state might have practical implication in human medicine as PPARα activators like fibrates are used for the therapy of chronic lymphocytic leukemia, microvascular complications in diabetes, and kidney diseases.—Wege, N., Schutkowski, A., Boenn, M., Bialek, J., Schlitt, A., Noack, F., Grosse, I., Stangl, G. I. Men and women differ in their diurnal expression of monocyte peroxisome proliferator-activated receptor-α in the fed but not in the fasted state.