一种免疫系统的杀手的追捕和消灭癌细胞的录像已经发布的科学家。研究人员利用先进的成像技术,在工作中捕捉到的无情的“杀手”T细胞。杀手,或细胞毒性T细胞,白血细胞的特殊作用破坏肿瘤细胞或已被病毒入侵的细胞。
吉莉安教授格利菲斯,剑桥大学的医学研究所所长,该研究,他说:“LED我们的内心都潜藏着连环杀手的主要功能是一次又一次地杀死一个军。“这些细胞巡逻我们的身体,识别和摧毁病毒感染的细胞和癌细胞,他们这样做明显的精度和效率。”满满一茶匙血液可能含有大约五百万的T细胞,每个测量10微米的长度,大约是人类头发宽度的十分之一。在视频中,T细胞显示为橙色或绿色无定形团块移动迅速,不断探索他们的环境。当一个杀手T细胞发现癌细胞(视频中的蓝色),膜的手指探索其表面以确认其身份。 T细胞结合到癌细胞注入毒蛋白(红色)下特殊的途径称为微管两细胞遇到的界面。
T然后穿刺癌细胞表面并将其 致命的货物。在我们的身体,在细胞挤在一起,重要的是,T细胞集中在其目标的致命的打击,否则会引起邻国,附带损害健康的细胞,”格利菲斯教授说。一旦毒素注入到癌细胞中,其命运是密封的,我们可以看着它枯萎和死亡。 “T细胞然后,渴望找到另一个受害人。” 研究人员拍下的画面通过高分辨率3D实时彩色成像,利用旋转盘共聚焦显微镜和晶格光片显微镜。 这些技术包括捕捉片通过对象和“缝合”在一起,整个细胞提供最终的三维图像。 采用这些方法,研究人员已经设法阐明秩序导致了致命的打击,从这些连环杀手的事件交付。由英国和美国科学家联合小组的研究发表在免疫了。
原文
Gotcha! Scientists capture astonishing video of 'killer' T-Cells fighting (and beating) cancer cells inside the body
A dramatic video of immune system 'hit men' hunting down and destroying cancer cells has been released by scientists.
Researchers used state-of-the-art imaging techniques to capture the ruthless 'killer' T-cells at work.
Killer, or cytotoxic, T-cells are white blood cells with the specialised role of destroying tumour cells or cells that have been invaded by viruses.
Professor Gillian Griffiths, director of Cambridge University's Institute for Medical Research, who led the study, said: 'Inside all of us lurks an army of serial killers whose primary function is to kill again and again.
'These cells patrol our bodies, identifying and destroying virally infected and cancer cells and they do so with remarkable precision and efficiency.'
One teaspoon full of blood might contain around five million T-cells, each measuring around 10 micrometres in length, or about a tenth of the width of a human hair.
In the video, the T-cells appear as orange or green amorphous blobs that move around rapidly, constantly investigating their environment.
When a killer T-cell finds a cancer cell (blue in the video), membrane 'fingers' explore its surface to confirm its identity.
The T-cell then binds to the cancer cell and injects toxic proteins (red) down special pathways called microtubules to the interface where the two cells meet.